In this Article I’ll lay out the Entire Supplement Protocol which I follow Year-Round. A Combination of these Supplements gives me the best possible Blood Work while Following my HRT Protocol and during a Full-Blown Steroid Cycle. Although Additional Supplementation might be Required when Blasting with Heavy Androgenic Compounds or Potent SARMs. Personally I don’t use SARMs and have no Interest in Experimenting with the further. I understand that some Readers still Enjoy to use them, that’s why I added SARMs to certain Sections of this Article, as I’ve seen enough Blood Work on Ostarine, Ligandrol, YK-11 & RAD-140 to know their Negative Effects on Lipid Levels & Liver Enzymes!
You can find the iHerb Links for Recommended Supplements at the Bottom of each Section.
iHerb 5% Discount Code: DTV967
Affiliate Link: https://www.iherb.com/?rcode=DTV967
If you’re Planning to use a lot of the Supplements mentioned below, you’re better off using a Supplement or Pill Organizer with Individual Dayplanner Boxes, which can be Removed and taken with you.
Apex MediChest: https://www.iherb.com/pr/Apex-MediChest-Large/27067
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Vitamins & Minerals
Multi-Vitamin (No Added Iron)
Dose: 1 Tablet Multi-Vitamin (No Added Iron) with Breakfast & Dinner (2 Tablets per Day)
There are many Multi-Vitamin Formulations available on the Market, I chose Alive! Multi-Vitamin as it has a very Wide Range of Vitamins, Minerals, Anti-Oxidants and other Beneficial Phyto-Chemicals. Alive! Supplies over 100% of the Daily Recommended Intakes (DRIs) for most of the Vitamins & Minerals in a 3 Tablets per Day Formulation. Only Iron, Fiber, Calcium, Magnesium, Sodium & Potassium are below the DRIs Concentrations, but can easily be Acquired through Nutrition or Mineral-Specific Supplementation.
Alive! also has a 3 Tablets per Day Multi-Vitamin Formulation with Added Iron, in the Form of Ferrous BisGlycinate Chelate, which is Preferred for Women as they Lose a Significant Amount of Iron during their Menstrual Cycle. Men should generally avoid Iron Supplementation unless they’re Deficient, as it might Severely increase Hematocrit & RBC Count when using Primobolan, Boldenone, Anadrol or other Erythrotropic Compounds.
I Generally Recommend 1 Tablet Alive! Multi-Vitamin with Breakfast & Dinner (2 Tablets per Day), as you’ll already get a Significant Amount of Micro-Nutrients from your Diet and the other Supplements mentioned in this Article, Over-Supplementation just makes you waste Money!
Alive! Multi-Vitamin (No Added Iron): https://www.iherb.com/pr/Nature-s-Way-Alive-Max3-Daily-Multi-Vitamin-No-Added-Iron-180-Tablets/4120
Alive! Multi-Vitamin (With Added Iron): https://www.iherb.com/pr/Nature-s-Way-Alive-Max3-Daily-Multi-Vitamin-180-Tablets/4119
Thorne Research Advanced Nutrients (No Added Iron): https://www.iherb.com/pr/Thorne-Research-Advanced-Nutrients-240-Capsules/18465
Vitamin B-100 Complex
Dose: 1 Tablet Vitamin B-100 Complex with Breakfast
The Body uses 8 Types of B-Vitamins in many Metabolic Processes that contribute to Energy Production, Creation of Red Blood Cells, Healthy Skin Cells & Neuronal Health. Below is a List of the 8 B-Vitamins and their Specific Functions in the Body:
• Thiamin (Vitamin B1); Glucose Metabolism, Creation of Neuro-Transmitters in the Brain & Nervous System, Production of Fatty Acids, Hormone Synthesis.
• Riboflavin (Vitamin B2); Energy Production, Fatty Acid, Medication & Steroid-Hormone Metabolism, Converting Tryptophan into Niacin (Vitamin B3), Converts Vitamin B6 into Coenzyme Pyridoxal 5-Phosphate (P5P).
• Niacin (Vitamin B3); Niacin converts into Coenzyme Nicotinamide Adenine Dnucleotide (NAD), which Contributes to 400 Enzymatic Reactions. Niacin also aids in Protein, Carbohydrate & Fat Metabolism for Energy Production within the Cells & Gene Expression of DNA in Cells.
• Pantothenic Acid (Vitamin B5); Aids in the Creation of New Coenzymes, Proteins & Fats, while Red Blood Cells utilize Pantothenic Acid for internal Energy Producion & Metabolism.
• Pyridoxine (Vitamin B6); Contributes to Amino Acid Metabolism, Immune Function & Brain Development as well as the Breakdown of Carbohydrates & Fats.
• Biotin (Vitamin B7); Breakdown of Protein, Carbohydrates & Fats, Communication among Cells, Regulation of DNA Replication, Synthesis & Gene Transcription.
• Folate or Folic Acid (Vitamin B9); Essential for DNA Replication, Vitamin & Amino Acid Metabolism as well as Cell Proliferation (Hyper-Plasia).
• Cobalamin (Vitamin B12); Creation of New Red Blood Cells, Regulation of DNA Replication & Synthesis, Function of Brain & Central Nervous System as well as Protein & Fat Metabolism.
Although the DRIs for most B Vitamins are already Achieved by Supplementing with 1 Tablet Alive! Multi-Vitamin with Breakfast & Dinner, I noticed that adding another 100mg or 100mcg of each B-Vitamin Significantly increased my Energy Levels throughout the Day.
NOTE: A Sustained or Time-Release B-100 Complex Formula with Breakfast increases Energy Levels more Effectively, compared to a B-100 Complex Formula in Rapid-Absorbing Capsules.
Now Foods B-100 Complex: https://www.iherb.com/pr/Now-Foods-B-100-Sustained-Release-100-Tablets/54510
Vitamin C Ester-C
Dose: 1 Tablet of 1,000mg Vitamin C Ester-C with each Meal (4-6 Tablets per Day, 4,000-6,000mg Total)
Vitamin C is an Essential Water-Soluble Vitamin with Potent Anti-Oxidant Properties as it draws Free Radicals from the Body. Vitamin C’s Chemical Structure Provides Minor Neuro-Protective Effects, Interacts with the Pancreas & Modulates Cortisol Levels.
In case of the Ketogenic Diet, Vitamin C is used as a Non-Metabolic Place Holder for Carbohydrates. Although Carb Intake is usually still around 30-50g per Day, these Carbs come from Vegetables and/or Nuts, which due to their relatively High Fiber Content as well as low Glycemic Index, appear not to Stimulate the Pathways that Starchy Carbohydrates from Rice, Oatmeal or Potato undertake in the Body. Vitamin C however, does undergo the same Pathways, but it not Bio-Available for Energy Production and Potentiates an Anti-Oxidant Effect instead. As Vitamin C is Structurally very Similar to Glucose (Simple Carbohydrates), it’s Transported through Similar Metabolic Pathways as Regular Glucose.
By Consuming 1,000mg Vitamin C with each Meal, these Processes stay Optimized and Active, even when Carbohydrates are (Severely) Restricted. This makes the Carb-Loading or Refeed Process for 1 or 2 Days per Week, much more Efficient and leads to less Water Retention during the Refeed, as well as the Day after the Refeed with a Surplus of Carbohydrates.
Vitamin C also has Minor Diuretic Effects, since Sodium Intake is usually increased while following a Ketogenic Diet to maintain Muscular Fullness & Hydration. The excess of Sodium is excreted alongside Vitamin C, resulting in Less Sub-Cutaneous (SubQ) Water Retention throughout the Day, without any loss of Muscle Fullness or Performance.
Recommended Dosing is 1,000mg Vitamin C (as Ester-C Calcium Ascorbate) with Citrus Bioflavonoids (Vitamin C Metabolites) per Meal, resulting in a Total of 4,000-6,000mg Vitamin C per Day. The Additional Calcium found in Ester-C Formulations, contributes to many Processes in the Body which require Calcium (Bone Density & Muscular Contractions) and helps to Control the Influx of Vitamin C into the Blood Stream. Ester-C is not a Time Released Formula, which don’t appear to have Special Benefits for Optimizing the Carb-Loading or Refeed Process. The Additional Bioflavonoids are just extra Anti-Oxidants which help to fight off Free Radicals, which are an unwanted Byproduct of High-Intensity Training for Hyper-Trophy.
American Health Vitamin C Ester-C: https://www.iherb.com/pr/american-health-ester-c-1000-mg-with-citrus-bioflavonoids-180-veggie-tabs/15080
Vitamin E Gamma-E Complex (Mixed Tocopherols & Tocotrienols)
Dose: 1 Capsule of 200-225iu with Breakfast & Dinner (2 Capsules per Day, 400-450iu Total) while using PEDs, 1 Capsule of 200-225iu with 4 Meals during Post Cycle Therapy (4 Capsules per Day, 450-900iu Total)
Vitamin E is a Group of 8 Fat Soluble Compounds that include 4 Tocopherols & 4 Tocotrienols. All Vitamin E Variants are Fat-Soluble Anti-Oxidants Protecting Cell Membranes from Reactive Oxygen Species.
Adequate Levels of Vitamin E helps to Manage SGPT/ALT & SGOT/AST Liver Enzyme Levels, Contributes to Brain Health through Anti-Oxidant Neuro-Protective Effects & Aids in Cardio-Vascular Lipid Management. Vitamin E also plays in Essential Role in the Hypothalamus-Pituitary-Testes/Adrenals-Axis (HPTA/HPAA), increases Sensitivity to Luteinizing Hormone (LH) & Follicle-Stimulating Hormone (FSH) and Manages Leydig Cell Function & Maintains Healthy Spermatogenesis.
NOTE: It is unclear which of the 8 Vitamin E Variants has the most Effect on Lowering Serum SGPT/ALT Liver Enzymes, Contributes to Brain Health or aids in HPTA & Spermatogenesis. You’re probably best off taking around 400-450iu Vitamin E consisting of Mixed Tocopherols combined with Mixed Tocotrienols per Day.
NOW Foods Gamma-E-Complex-Advanced: https://www.iherb.com/pr/Now-Foods-Gamma-E-Complex-Advanced-120-Softgels/299
California Gold Nutrition Sunflower-Vitamin-E-with-Mixed-Tocopherols: https://www.iherb.com/pr/California-Gold-Nutrition-Sunflower-Vitamin-E-with-Mixed-Tocopherols-400-IU-90-Veggie-Softgels/76864
Vitamin D3 (Cholecalciferol)
Dose: 1 Capsule of 5,000iu Vitamin D3 with Breakfast while using PEDs, 1 Capsule of 5,000iu Vitamin D3 with Breakfast & Dinner during Post Cycle Therapy (2 Capsules per Day, 10,000iu Total), 3 Capsules of 1,000iu Vitamin D3 with Breakfast when using Vitamin K Complex Supplements that also contain 2,000iu Vitamin D3 (4 Capsules per Day, 5,000iu Total)
Vitamin D3 is an Essential Fat-Soluble Nutrient that the Body can Synthesize in the Skin from Exposure to Sunlight. The Body Produces Vitamin D from Cholesterol, provided there is an Adequate Amount of UV Light from the Sun (UV Index over 3) or Tanning Bed. In order to get Sufficient Amounts, a Person Generally needs 20 Minutes of Full-Body Sun Light Exposure. Vitamin D is also found in Fish, Eggs & Dairy Products, albeit in Moderate Amounts which typically don’t reach the DRI of 600 IU Vitamin D per Day.
Supplemental Vitamin D3 is Associated with a Wide Range of Health Benefits, including; Increased Cognition & Memory, Improved Immune System, Management in Sex-Hormone Levels, Management in Bone Health & Overall Sense of Wellbeing. Supplementation can also reduce the Risks of Cancer, Heart & Cardio-Vascular Disease, Diabetes & Multiple Sclerosis.
NOTE 1: It’s almost Impossible to get Adequate amounts of Vitamin D3 from your Diet, you’d either need to Tan Daily or use Supplements. World’s Healthiest Foods lists Salmon, Sardines & Tuna as the Highest Sources of Dietary Vitamin D3, but when I looked at the Nutritional Content of these Foods on SELF Nutrition Data, it appears that their Vitamin D3 Content is Insufficient (50-100 IU Total) to reach the DRI Minimum of 600 IU per Day. You’re better off with a 1,000 IU Vitamin D3 Supplement (or more) or 20 Minutes of Full-Body Sunbathing or Tanning per Day!
Jarrow Formulas Vitamin D3 1,000iu: https://www.iherb.com/pr/Jarrow-Formulas-Vitamin-D3-Cholecalciferol-1-000-IU-100-Softgels/40600
Jarrow Formulas Vitamin D3 2,500iu: https://www.iherb.com/pr/Jarrow-Formulas-Vitamin-D3-Cholecalciferol-2-500-IU-100-Softgels/15009
Jarrow Formulas Vitamin D3 5,000iu: https://www.iherb.com/pr/Jarrow-Formulas-Vitamin-D3-Cholecalciferol-5-000-IU-100-Softgels/22926
Vitamin K Complex (D3, K1, K2 MK-4 & K2 MK-7)
Dose: 1 Capsule of 2,230mcg Vitamin K-Complex with Breakfast while Cruising, 1 Capsule of 2,230mcg with Breakfast & Dinner (2 Capsules per Day) while Blasting.
Jarrow Formulas K-Right: 2,000iu Vitamin D3, 500mcg Vitamin K1 (Phytonadione), 1,500mcg Vitamin K2 MK-4 (Menaquinone-4) & 180mcg Vitamin K2 MK-7 (Trans-Menaquinone-7) per Capsule, 2,180 Vitamin K Total
Life Extension Super K: 1,500mcg Vitamin K1 (Phytonadione), 1,000mcg Vitamin K2 MK-4 (Menaquinone-4) & 100mcg Vitamin K2 MK-7 (Trans-Menaquinone-7) per Capsule, 2,600 Vitamin K Total
Vitamin K is an Essential Fat-Soluble Vitamin which plays a Key Role in Blood Coagulation. Vitamin K is Predominantly found in Dark Green Leafy Vegetables, including: Kale, Spinach, Mustard Greens, Collard Greens, Beet Greens, Parsley, Broccoli & Brussels Sprouts as well as Matcha Green Tea & Natto (Japanese Fermented Soybeans). These Sources of Vitamin K, also contain Significant Amounts of PyrroloQuinoline Quinone (PQQ). Since Vitamin K2 is a result of Bacterial Fermentation, it can also be found in some Animal Products, including; Milk & Cheese.
Adequate Levels of Vitamin K show support for Healthy Blood Coagulation, while Higher Levels of Vitamin K provide Additional Benefits for the Cardio-Vascular System & Bone Health. There it Contributes to Calcium Transport and Shuttles Calcium from the Blood Stream, into Bone & Muscle Tissue (for improved Muscular Contractions). This reduces Potential for Calcification & Stiffening of the Arteries, which further reduces the Risk of Cardio-Vascular Diseases. Vitamin K may also help to Regulate Insulin Sensitivity, although Research is rather Limited at this Point.
Similar to Vitamin D3, its Difficult to obtain High Amounts of Vitamin K from Dietary Sources alone, more Specifically; Vitamin K1 (Phylloquinone), Vitamin K2 (MK-4 Menaquinone-4) & Vitamin K2 (as Natural MK-7 Menaquinone-7) which contribute to Cardio-Vascular & Bone Health.
NOTE: Vitamin K Supplements often Contain Vitamin D3, since both Vitamins contribute to Bone Health and have been shown to reduce Risk of Cardio-Vascular Disease. When Supplementing with 1 or 2 Capsules Jarrow Formulas K-Right per Day, you already get 4,000iu Vitamin D3 alongside 4,360mcg Vitamin K1, K2-MK4 & K2-MK7, plus whatever Vitamin D3 you’re Acquiring through Dietary means or Sunlight Exposure. In this case Additional Vitamin D3 Supplementation might not be Required, unless aiming for 5,000-10,000iu Vitamin D3 per Day!
Jarrow Formulas K-Right: https://www.iherb.com/pr/Jarrow-Formulas-K-Right-Vitamin-K-Complex-60-Softgels/69334
Life Extension Super K: https://www.iherb.com/pr/Life-Extension-Super-K-90-Softgels/90368
Magnesium Glycinate, BisGlycinate or Citrate
Dose: 1 Tablet of 200mg Magnesium Glycinate, BisGlycinate or Citrate with each Meal (4-6 Tablets per Day, 800-1,200mg Total)
Magnesium is an Essential Dietary Mineral which is used in over 300 Separate Processes in the Body. Sufficient Intake Contributes to Blood Pressure Management, Insulin Sensitivity & Blood Glucose Management, Relaxation of Neuronal Activity according to the Circadian Rhythm & Relaxation of Muscle Tissue Post-Contraction. Maintaining Healthy Magnesium Levels is also Associated with a Protective Effects against Depression & Attention Deficit Hyperactivity Disorder (ADHD).
The Majority of Magnesium in your Body is bound to Proteins or Stored in your Skeleton. Bones contain about half of the Body’s Magnesium as it’s necessary for the Formation of Bone & Teeth and for normal Nerve & Muscle Function. Many Enzymes in the body depend on Magnesium to Function Properly. Magnesium also plays an Important Role in Metabolism of Calcium and Potassium. The Level of Magnesium absorption depends on how much the Body needs, otherwise Magnesium remains in the Intestinal Tract and acts as a Mild Laxative.
NOTE: A simple way to assess how many Milligrams of Magnesium your Body requires is by slowly increasing Supplemental Forms of Magnesium (Glycinate, BisGlycinate or Citrate) until you get loose Stool or Diarrhea. Then you reduce the Dose until you no longer Experience these Side-Effects, that’s the Optimal Amount of Dietary & Supplemental Magnesium you can absorb every Day!
Magnesium is very Beneficial for Healthy Blood Pressure and Intense Hypertrophy Training as it helps to relax the Muscles after a Hard Contraction and aids to lower the Weigh under Tension. A Controlled Negative results in a large portion of the Hypertrophy Signals for Muscle Growth! We end up using a lot of Magnesium this way as the Negative Portion of the Rep should always be performed Slower for Additional Time-Under-Tension (TUT), compared to the Positive Portion, where Calcium is used!
It’s relatively easy to get Adequate Amounts of Magnesium from your Diet as it’s found in most Foods like Fruits, Vegetables, Nuts and Fish, which are all commonly Consumed by Body Builders & Fitness Enthusiasts. In order to supply more Magnesium for a better Controlled Eccentric Contraction, you can use Supplements like Magnesium Citrate or (Bis)Glycinate which are the most Bio-Available Forms of Magnesium. Personally I take 200mg Magnesium Glycinate Tablets with each Meal, up to 1,200mg Supplemental Magnesium per Day, on Top of the 800-1,000mg I get from my Diet already!
KAL Magnesium Glycinate: https://www.iherb.com/pr/KAL-Magnesium-Glycinate-400-400-mg-180-Tablets/18943
Lake Avenue Magnesium BisGlycinate: https://www.iherb.com/pr/Lake-Avenue-Nutrition-Magnesium-Bisglycinate-200-mg-Per-Serving-240-Tablets/96279
Now Foods Magnesium Citrate: https://www.iherb.com/pr/Now-Foods-Magnesium-Citrate-240-Veg-Capsules/78201
Blood Work Support & Organ Health
N-Acetyl Cysteine (NAC)
Dose: 1 Tablet of 1,000mg NAC with Breakfast & Dinner (2 Tablets per Day, 2,000mg Total)
N-Acetyl Cysteine (NAC) is a Supplement that provides Building Blocks for Glutathione Production in the Liver and other Cells of the Body, it’s also used as Medication to treat Paracetamol (Acetaminophen) Overdose or to loosen Thick Mucus in Individuals with Cystic Fibrosis. It is on the World Health Organization’s (WHO) List of Essential Medicines, which lists the Safest and most Effective Medicines needed in the Bodies Health System.
Glutathione exists in Reduced (GSH) and Oxidized (GSSG) States. The Ratio of Reduced Glutathione to Oxidized Glutathione within Cells is a measure of Cellular Oxidative Stress. In Healthy Cells and Tissue, more than 90% of the Total Glutathione Pool is in the Reduced Form (GSH), with the Remainder in the Oxidized Form (GSSG). An Increased GSSG-to-GSH Ratio is Indicative of Oxidative Stress, by a constant Influx of NAC to create more Reduced Glutathione, this healthy Ratio is Maintained and GSH Protects Cells by Neutralizing Reactive Oxygen Species (converting to GSSG in the Process)
Glutathione is also Employed for the Detoxification of Methyl-Glyoxal & Formaldehyde, both Toxic Metabolites Produced under Oxidative Stress. It also Maintains Exogenous Anti-Oxidants such as Vitamin C & E in their Reduced (Active) States.
Glutathione is Beneficial for Liver Health (as well as Kidney Health) as it Facilitates Metabolism of Xenobiotics by Catalyzing their Conjugation to Lipophilic Xenobiotics, which Facilitates their Excretion or additional Metabolism.
Low Glutathione is commonly observed in Wasting Diseases & Negative Nitrogen Balance, as seen in Cancer, HIV/AIDS, Sepsis, Physical Trauma, Burns, Athletic Overtraining or after Periods of Starvation.
Systemic Bio-Availability of Orally Consumed Glutathione is very low, because the Tri-Peptide Molecule is subject to Disassembly by Protease Enzymes in the Intestinal Tract. As well as an Absence of a Specific Carriers for Glutathione at the level of Cell Membrane. This makes NAC the most Suitable Supplement to increase the Cell’s Concentration of Glutathione as it’s Produced Directly inside the Cell, by using NAC as a Building Block.
NAC is predominantly Metabolized in the Liver, where it’s partially used to create Glutathione as needed by the Body. Taking more NAC then the Recommended Dosage of 1,800-2,000mg per Day has not been shown to increase Glutathione Levels in the Body. NAC by itself has Anti-Inflammatory Effects by Inhibiting & Modulating Cytokine Synthesis.
NOTE 1: Alpha Lipoic Acid (ALA) & Glycine can also be used to Synthesize Glutathione within the Cells of the Body!
NOTE 2: Glutathione works Synergistically with Vitamin C, E & D3, which also need to be consumed in Adequate Doses according to the DRIs for your Sex & Age Group. These Micro-Nutrients HIGHLY Complement each other!
Jarrow Formulas N-A-C Sustain 600mg: https://www.iherb.com/pr/Jarrow-Formulas-N-A-C-Sustain-N-Acetyl-L-Cysteine-600-mg-100-Tablets/135
Now Foods NAC 1,000mg: https://www.iherb.com/pr/Now-Foods-NAC-1000-mg-120-Tablets/59157
Glutathione Reduced (GSH)
Dose: 1 Capsule of 500mg OPITAC™ Glutathione (Reduced) with Breakfast & Dinner (2 Capsules per Day, 1,000mg Total)
The Common Consensus it that Oral Glutathione Supplementation isn’t Bio-Available as it breaks down in the Stomach and doesn’t get Absorbed in it’s Active Form. Recently several Studies have been Published which do show that OPITAC™ Oral or Sublingual Glutathione Formulations have Potential for Bio-Availablity. The Exact Formulation behind OPITAC Glutathione is currently unknown. There are a few Liposomal Glutathione Formulations with OPITAC™ Glutathione as well, which appears to increase Bio-Availability further, although I haven’t tried them Personally.
In an Experiment where I replaced 2,000mg NAC with 1,000mg OPITAC™ Glutathione per Day, for a Month, I noticed that my Skin got Lighter, which is a Common Side-Effect of Glutathione Injections. Comparing my Blood Work Results I didn’t notice a Significant Difference between NAC or OPITAC™ Glutathione, which makes me Conclude that both Supplements Contribute to Health in a Similar Fashion. Currently I’m running an Experiment where I Supplement 2,000mg NAC & 1,000mg OPITAC™ Glutathione per Day, but I’ll have to see my Blood Work Results before I draw a Conclusion. I will update this Section once I see some Evidence this Combination is Beneficial, for now either 2,000mg NAC or 1,000mg OPITAC™ Glutathione will Suffice to keep Health Markers in close to the Reference Range while using Moderate Dosages of PEDs!
Jarrow Formulas Glutathione Reduced: https://www.iherb.com/pr/Jarrow-Formulas-Glutathione-Reduced-500-mg-60-Veggie-Caps/355
TauroUrsoDeoxyCholic Acid (TUDCA):
Dose: 1 Capsule of 500mg TUDCA with Breakfast & Dinner (2 Capsules per Day, 1,000mg Total) while Cruising, 2 Capsules of 500mg TUDCA with Breakfast & Dinner (4 Capsules per Day, 2,000mg Total) while Blasting with Oral Steroids.
TauroUrsoDeoxyCholic Acid (TUDCA) is a Water Soluble Bile Acid, it is the Taurine Conjugated Form of UrsoDeoxyCholic Acid (UDCA). TUDCA has been used in Ancient Asian Pharmacopoeias for its supposed Health Benefits, while UDCA is used in Several Countries for the Treatment of Gallstones & Liver Cirrhosis.
Currently, TUDCA is not Approved by the American Food & Drug Administration, but UDCA is Approved for the treatment of Primary Biliary Cirrhosis (PBC). Ongoing Research has shown that TUDCA has Diminishing Apoptotic Effects (Programmed Cell Death), with potential application in Heart Disease, Parkinson’s Disease & Stroke. TUDCA prevents Apoptosis with its role in the BAX Pathway, which is Trans-Located to the Mitochondria to Release Cytochrome-C, which in turn, Initiates the Cellular Pathway of Programmed Cell Death. TUDCA Prevents BAX from being transported to the Mitochondria.
Body Builders Typically use TUDCA in Combination with Soluble Fiber to reduce Serum Liver Enzymes & Cholesterol Levels as TUDCA increases Bile Acid Flow into the Intestinal Tract, where it can bind to Soluble Fiber for Excretion. While this Effectively lowers Cholesterol Levels, SGOT/AST, SGPT/ALT, Gamma-GT and most other Liver Related Blood Markers, it does not Prevent, Reduce or Protect People from Liver Damage, unless they’re Suffering from Biliary Obstruction or Poor Bile Acid Production. TUDCA reduces the Serum Concentrations of these Health Markers, by promoting Excretion of Bile Acids, which contain Toxins & Metabolic Waste Products.
TUDCA does not Directly Prevent the Damaging Effects of Performance Enhancing Drugs (PEDs), although it does Contribute to Overall Detoxification and prevent Recycling / Reabsorption of Toxins & Metabolic Waste Products into the Blood Stream, minimizing the Harmful Effects of most PEDs. Since many PEDs are also Metabolized by the Liver, this Detoxification Process can be Optimized with TUDCA in order to Remove the Metabolized Hormones & Medication from the Body.
A Welcome Side-Effect of TUDCA is increased Bowel Movements, as the Additional Bile Acid helps to Lubricate Feces & Intestinal Wall, making it easier to pass Stool along. Although this might be Cumbersome when you’re working Office or Manual Labor, it’s a Blessing for Full-Time Body Builders in the Offseason. When you’re consuming 4,000-6,000 Calories per Day from Nutritious Food Sources, Food Volume is rather High and can make you feel Incredibly Full by the End of the Day. TUDCA allows Offseason Body Builders to pass Food along Faster, causing them to Feel a lot less Bloated at the End of the Day.
Depending on the Severity of the Increased Liver Markers, a Dosage of 250-2,000mg TUDCA for 4-8 Weeks is usually enough to bring most Liver Markers back into the Reference Range, as long as Heavy PED use (especially Oral AAS or SARMs) is Discontinued. TUDCA use must be combined with Dietary Fiber Intake of atleast 38g per Day, as well as 5-10g Psyllium Husk Fiber before Bed to promote further Detoxification.
NOTE: UDCA isn’t as effective in Increasing Liver Bile Acid Flow as TUDCA as it’s not Conjugated with Taurine. Taking UDCA with Taurine doesn’t cause additional Conjugation and doesn’t increase the Effectiveness of UDCA. TUDCA should always be the Supplement of Choice when aiming to Improve Liver Health & Reduce Serum Liver Enzymes!
Nutricost TUDCA 500mg: https://nutricost.com/products/nutricost-tudca-250mg-capsules?variant=31505321394250
Dose: 1 Capsule of 100mg DIM with Breakfast & Dinner (2 Capsules per Day, 200mg Total) while Cruising
Diindolylmethane (DIM) is a Component of Indole-3-carbinol (I3C) found in Broccoli, Kale & Cauliflower. In order to get an Effective Dose of DIM, you’d have to consume Several Hundred Grams of Broccoli, Kale or Cauliflower per Day. Therefore, it’s generally Advised to take DIM in Supplemental Form.
DIM is Classified as a Phyto-Estrogen, which can aid in the Detoxification of other Phyto-Estrogens through the Liver. DIM also has a Potent Effect on Estrogen Metabolism and helps to keep Levels between different Estrogens relatively Balanced, by preventing Drastic increases or decreases in Serum Concentrations of either Estrone (E1), Estradiol (E2) or Estriol (E3).
In Supplemental Amounts, DIM can both Inhibit the Aromatase Enzyme and prevent Conversion of Testosterone into Estradiol (E2), while DIM can also act on more Potent Forms of Estrogen and Convert them into less Potent Forms or Metabolites. This Conversion reduces the overall Effects of Estrogens & Phyto-Estrogens in the Body. However, taking too much DIM at once, might actually cause it to act as a Catalyst for Aromatase Activity and increase Estrogen Synthesis.
General Recommendations for Estrogen Management on a Traditional TRT or HRT Protocol, of while Cruising on Moderate Dosages of Testosterone, 100mg DIM with Breakfast & Dinner is usually enough to keep Serum Estrogen Levels in the Desired Range. However, since Aromatase Activity is increased in Individuals over 15% Body Fat, they might Require Aromatase Inhibitors to Control their Serum Estrogen Levels.
Source Natural Diindolylmethane: https://www.iherb.com/pr/Source-Naturals-DIM-Diindolylmethane-100-mg-180-Tablets/53958
Calcium D-Glucarate (CDG)
Dose: 1 Capsule of 500mg CDG with Breakfast & Dinner (2 Capsules per Day, 1,000mg Total) while Cruising
Calcium D-Glucarate (CDG) supplies Glucarate for a Detoxification Process where a Glucuronide is attached to a Hydrophobic Molecule to make it more Water Soluble. Many Toxins, Phyto-Estrogens & ALL Sex-Hormones are Hydrophobic Molecules, that’s why the Majority of Sex-Hormones are Bound to Albumin or Sex Hormone-Binding Globulin (SHBG), or Subject to Sulfuration by Steroid Sulfatase (STS), for Transport through the Blood Stream. Glucuronidation Facilitates the Kidneys to remove these Water-Soluble Molecules from the Body, as Kidney Filtration is Highly Dependent on Water & Electrolyte Flow.
The Maximum Detoxifying Effect is only reached at Higher Dosages of 100-200mg CDG per 1kg or 50-100mg CDG per 1lbs of Body Weight. When using CDG in Supplemental Form, we’re not looking to Completely Detox the Body of ALL Toxins & Hydrophobic Sex-Hormones, we’re merely trying to prevent the Recycling of Glucuronide when Serum Concentrations drop below Optimal Levels. When this happens, Toxins & Sex-Hormones aren’t Completely Excreted of by the Kidneys as Glucuronide is Cleaved Off, before the Toxins & Sex-Hormones can reach the Kidneys and be Excreted through Urine.
NOTE: If an Excessively High Dose of CDG is used to reduce Toxins & Phyto-Estrogens, Circulation Levels of Neuro-Steroids & Sex-Hormones will also all be reduced for the Duration CDG is Supplemented at Higher Dosages!
Source Natural Calcium D-Glucarate: https://www.iherb.com/pr/Source-Naturals-Calcium-D-Glucarate-500-mg-120-Tablets/1090
Fish Oil: Omega-3 EPA & DHA
Dose: 1 Capsule of 600-800mg EPA & DHA from Fish Oil with each Meal (4-6 Capsules per Day, 2,400-4,800mg EPA & DHA Total)
Jarrow Formulas EPA-DHA Balance: 400mg EPA & 200mg DHA per 1,000mg Capsule (600mg Omega-3 Fatty Acids Total)
California Gold Nutrition Omega-800: 480mg EPA, 320mg DHA & 40mg other Omega-3 per 1,000mg Capsule (840mg Omega-3 Fatty Acids Total)
Fish Oil is a Common Term used to refer to 2 Kinds of Omega-3 Fatty Acids; EicosaPentaenoic Acid (EPA) & DocosaHexaenoic Acid (DHA). Both of these Healthy Omega-3 Fatty Acids are found in Fish (Salmon, Herring, Anchovies, Tuna & Sardines) & Phyto-Plankton. The Omega-3 contained in Flax Seeds or Chia Seeds is Alpha-Linolenic Acid (ALA), which requires Conversion into EPA & DHA inside the Body. The Rate of Conversion is Extremely Low, but can be Moderately Improved by reducing Omega-6 & Omega-9 Intake as they Compete for the same Enzymes which Promote ALA’s Conversion into EPA & DHA.
EPA & DHA are involved in Regulating a Wide Range of Biological Processes, including; the Inflammatory Response to Injury & Oxidation (Exercise Induced), Metabolic Signaling Pathways, Brain Function, Insulin Sensitivity & Serum Lipid Management.
Adequate EPA & DHA Intake from Fish or Supplements has shown to reduce Serum Triglyceride & Cholesterol Levels, improve Blood Pressure in Hypertensive Cases, improve Mood & Sense of Wellbeing (through reduction of Neuro-Inflammation), lower Systemic Inflammation, act as Natural Anti-Coagulant, increase Insulin Sensitivity and contribute to Hyper-Plasia as both EPA & DHA are found in High Concentrations in the Cell Membraness
I prefer to take 1 Capsule of 1,000mg Fish Oil containing 600-800mg EPA & DHA with each Meal to increase it’s Omega-3 Content and improve Insulin Sensitivity throughout the Day.
NOTE 1: Many Fish Oil Supplements may contain Harmful Lipid Peroxides (Oxidized Fats that act as Free-Radicals and can Damage Cells). These Peroxides make the Supplement go “Rancid” The easiest way to assess if your Fish Oil has gone Rancid is by opening the Gel Capsule and Smelling & Fasting it’s Content.
NOTE 2: Fish Oil Supplements come in many different Concentrations & Potencies, only buy Supplements which is over 50% EPA & DHA (most are only 30% EPA & DHA). Pharmaceutical Grade Fish Oil that’s approved for Clinical Settings has been Tested for Peroxides, Heavy Metals and other Contaminents & Toxins, these Formulations usually contain over 60% EPA & DHA!
Jarrow Formulas EPA-DHA Balance: https://www.iherb.com/pr/jarrow-formulas-epa-dha-balance-240-softgels/7929
California Gold Nutrition Omega-800: https://www.iherb.com/pr/California-Gold-Nutrition-Omega-800-by-Madre-Labs-Pharmaceutical-Grade-Fish-Oil-80-EPA-DHA-Triglyceride-Form-1000-mg-90-Fish-Gelatin-Softgels/85180
Krill Oil: Astaxanthin & Omega-3 EPA & DHA
Dose: 1 Capsule of 1,000mg Krill Oil with Breakfast & Dinner (2 Capsules per Day, 840mg Omega-3 Fatty Acids Total) while Blasting
Jarrow Formulas Krill Oil: 120mg EPA, 70mg DHA, 260mg other Omega-3 Fatty Acids, 650mg Phospholipids & 115mcg Astaxanthin per 1,000mg Capsule (450mg Omega-3 Fatty Acids Total)
California Gold Nutrition Antarctic Krill Oil: 120mg EPA, 60mg DHA, 240mg other Omega-3 Fatty Acids, 400mg Phospholipids & 300mcg Astaxanthin per 1,000mg Capsule (420mg Omega-3 Fatty Acids Total)
Krill Oil is derived from Krill, which is a Type of Crustaceans that Predominantly Feeds on Phyto-Plankton & Algae. This supplies the Majority of their Omega-3 Content. Krill contains the same 2 Fatty Acids as Fish Oil; EicosaPentaenoic Acid (EPA) & DocosaHexaenoic Acid (DHA). However, a large Portion of the EPA & DHA in Krill is in the Form of a Phospholipid, with a Phosphate Group on the End of the Fatty Acid. This results in Higher Bio-Availability of Krill Oil compared to Fish Oil, resulting in similar Beneficial Effects Associated with Omega-3 Supplementation, albeit at much Lower Dosages when using Krill Oil.
Astaxanthin is a Pink-Red Pigment & Keto-Carotenoid found in various Algae, Animals who feed on the Algae, such as Salmon, Red Trout, Red Sea Bream, Flamingos & Crustaceans (including Shrimp, Crab, Lobster AND Krill). When the Predominant Food Source of Animals like Krill or Flamingos is Algae, Astaxanthin causes Pink-Red Pigmentation of the Shell, Skin & Feathers. Although Astaxanthin is Chemically similar to Beta-Carotene, it Provides Different Health Benefits at much Lower Amounts.
Krill Oil Supplements with Astaxanthin from are known to have Additional Heart Health Protective Effects due to a Cascade of Benefits, including: reduced Systemic Inflammation Levels through Anti-Inflammatory Properties, reduced Oxidative Stress through Anti-Oxidant Properties, improved Serum Lipid Management, reduced Perception of Stress as well as increased Cognitive Function, Overall Sense of Wellbeing & General Anti-Aging.
Krill Oil Supplementation on top of Fish Oil Supplementation appears to be more Beneficial over 30 Years of Age when the Body reduces Synthesis of EPA & DHA and Benefits from the Anti-Aging Properties of Phospholipids with Astaxanthin. Most of the Benefits are seen at Dosages between 1,000-3,000mg Krill Oil per Day, when using Fish Oil with each Meal, 2,000mg Krill Oil per Day while Blasting (to reduce Oxidative Stress) appears to be Sufficient. People over 50 Years of Age can Supplement with Krill Oil Daily, regardless of the Amount of PEDs they’re using.
Jarrow Formulas Krill Oil: https://www.iherb.com/pr/Jarrow-Formulas-Krill-Oil-120-Softgels/74793
California Gold Nutrition Antarctic Krill Oil: https://www.iherb.com/pr/California-Gold-Nutrition-Antarctic-Krill-Oil-with-Astaxanthin-RIMFROST-Natural-Strawberry-Lemon-Flavor-1000-mg-120-Fish-Gelatin-Softgels/71631
Gamma Linolenic Acid (GLA)
Dose: 2 Capsules of 1,300mg Evening Primrose Oil or 1,000mg Black Currant oil with Breakfast & Dinner (2 Capsules per Day, 2,000-2,600mg Total for 240-280mg Gamma Linolenic Acid) while Blasting
Now Foods Super Evening Primrose Oil: 120mg GLA per 1,300mg Capsule
Now Foods Black Currant Oil: 140mg GLA & 104mg ALA per 1,000mg Capsule
Evening Primrose Oil (EPO) is derived from the Seeds of the Evening Primrose Plant, which is Native to North America. Black Currant Oil (GCO) is derived from the Seeds of the Black Currant Plant’s Berries, which is Native to Central & Northern Europe and Northern Asia. Both EPO & GSO are Concentrated Sources of Gamma Linolenic Acid (GLA), an Omega-6 Fatty Acid found in Plant Sources.
GLA is also found in Varying Amounts in Edible Hemp Seeds, Oats, Barley & Spirulina. Genetically Modified Safflower Oil contains around 40% GLA, Borage Oil contains 20% GLA, Evening Primrose Oil Supplements range from 8-10% GLA & Black-Currant Oil contains 15-20%.
The Human Body Produces Sufficient Amount of GLA from Linoleic Acid (LA), which differs from Alpha-Linoleic Acid (ALA) found in Flaxseeds, Chia Seeds & Walnuts. Linoleic Acid is mostly found in Meat and some Vegetable Oils, which Body Builders & Fitness Enthusiasts tend to avoid!
Although Direct Supplementation of GLA is generally not Required, it has been shown to Promote Several Health Benefits for Body Builders & Fitness Enthusiasts, including: reduced Acne Formation, improved Overall Skin Health, reduced High Blood Pressure, contributes to Heart & Cardio-Vascular Health. These Effects are seen at Low Dosages of 240-280mg GLA per Day while Cruising or Blasting, on top of the GLA you’re Acquiring through Dietary means.
NOTE 1: Both Evening Primrose Oil & Black-Currant Oil have Minor Anti-Coagulant Properties and can reduce Blood Clotting when combines with Anti-Platelet or Anti-Clotting Medications. Overuse of EPO or GCO with these Medications might increase the Risks & Complications of Bleeding.
NOTE 2: GLA can Cascade into Arachidonic Acid, which has shown to be Beneficial for Muscle Growth due to its Pro-Inflammatory Effects in Muscle Tissue Post-Workout.
Now Foods Super Evening Primrose Oil: https://www.iherb.com/pr/Now-Foods-Super-Primrose-Evening-Primrose-Oil-1300-mg-120-Softgels/851
Now Foods Black Currant Oil: https://www.iherb.com/pr/Now-Foods-Black-Currant-Oil-1-000-mg-100-Softgels/46686
Kaneka Ubiquinol CoQ10: Shilajit & PQQ
Dose: 1 Capsule of 100mg Kaneka Ubiquinol CoQ10 with Breakfast & Dinner (2 Capsules per Day, 200mg Total) while Cruising, another 2-3 Capsules of 100mg Kaneka Ubiquinol CoQ10 1 Hour Pre-Workout while Blasting (4-5 Capsules per Day, 400-500mg Total)
Coenzyme Q10 (CoQ10) is a Molecule Produced in the Body that Aids Mitochondria during Energy Production and is also part of the Endogenous Anti-Oxidant System.
Ubiquinol is CoQ10 that has been Converted for use in the Cellular Energy Production Process. It’s Directly Associated with over 95% of the Body’s Cellular Energy Production. In Supplemental Form, Ubiquinol also helps to Protect the Cells from Oxidative Stress, which can cause Damage to Proteins, Lipids & DNA.
Ubiquinol works by Transferring Electrons in the Proton-Pump Process that Mitochondria use to Produce Energy within the Cells of the Body, especially in the Heart which Requires a Significant Amounts of Cellular Energy to Function Properly! Ubiquinol is Critical in the Production of ATP, the body’s Primary Fuel Source. The Energy Demands of the Heart for ATP are among the Highest in the body (after the Brain, which requires mostly Glucose or Ketones for energy)
Converting Conventional CoQ10 (Ubiquinone) into Ubiquinol becomes harder and less Efficient after the Age of 40. Ubiquinol Supplements require no Conversion, making them a more Beneficial Option for many People over 40 compared to CoQ10 Supplementation, as well as for People who are considerably Younger!
The Ubiquinol CoQ10 made by Kaneka is Bio-Identical to the Ubiquinol made Naturally in the Body, this is the preferred form of CoQ10 you should use as a Supplement. Kaneka Nutrients Produces the only Yeast-Fermented and Naturally-Derived CoQ10 that’s Commercially Available, since 1977. They make Ubiquinol CoQ10 in the United States & Japan, then sells the Nutrient to Supplement Companies who use the Ingredient in their Branded Ubiquinol Supplement Products, adding some extra Costs to the End Consumer. When you buy Kaneka Ubiquinol Supplements, make sure it’s produced in either the USA or Japan and Ships from there also, this will save you a few Dollars per Bottle!
If you’re also looking to increase Power Output and improve your Workout Quality while Blasting; 200-300mg Ubiquinol taken 1 Hour Pre-Workout will produce a Significant Improvement! Although this will add another 1-2 USD to your Daily Supplement Expenses.
Shilajit Fulvic Acid
Shilajit or Mumijo is a Blackish-Brown Powder or an Exudate found in the Himalayas, Nepal, Russia, Mongolia and in the north of Chile, where it is called Andean Shilajit. It contains Approximately 15–20% Fulvic Acid and a Small Amount of Minerals and Metabolites derived from Fungi.
Shilajit has been used in Ayurvedic Medicine & Traditional Healing Practices for Centuries, including; Diabetes, Altitude Sickness, Asthma, Heart Ailments & Digestive or Nervous Disorders. There is some Preliminary Evidence that it can also reduce Inflammation, Stimulate the Immune System, Enhance Performance & Boost Testosterone Production, which seems to be a Popular Attribute of most Ayurvedic Supplements…
Fulvic Acid is a Byproduct of Decomposition and can be Extracted from Compost or Soil. It has several Unique Properties, one of which is Improving Mitochondrial Function, when Combined with CoQ10 or Ubiquinol. Studies showed that Mitochondrial Adenosine TriPhosphate (ATP) Production was Significantly Elevated, when CoQ10 or Ubiquinol were Combined with Fulvic Acid.
Personally I take 1 Capsule of 250mg Shilajit Fulvic Acid with Breakfast & Dinner If I Train in the Morning I take my Breakfast Serving of Shilajit Fulvic Acid with 200-300mg Kaneka Ubiquinol CoQ10, 1 Hour Pre-Workout. If I Train in the Evening I take my Dinner Serving of Shilajit & Ubiquinol Pre-Workout. With this Dosing Protocol I don’t exceed 500mg Shilajit Fulvic Acid Total per Day
PyrroloQuinoline Quinone (PQQ)
PyrroloQuinoline Quinone (PQQ) is a Micro-Nutrient that Acts as an Anti-Oxidant in the Body, protecting Cells & Mitochondria from Free Radicals (Oxidants). PQQ is naturally occurring in some Food Sources, albeit in Low Amounts. Matcha Green Tea & Natto (Japanese Fermented Soybeans), Spinach, Parsely & Green Peppers contain notable Amounts of PQQ & Vitamin K, although not in the Concentrations where a few Servings of these Food Sources, provide Adequate Amounts of PQQ.
Like Ubiquinol & Shilajit Fulvic Avid, PQQ improved Mitochondrial Function and has also been shown to increase Mitochondrial Content with Cells, including in the Brain & Heart.
I found that 20mg PQQ with my Pre-Workout Combination of 200-300mg Ubiquinol & 250mg Shilajit Fulvic Acid was enough give me a Noticeable Boost during the Workout. I’ve experimented with 40mg PQQ Pre-Workout as well as 20mg PQQ with Breakfast & Dinner, but I can’t say that I noticed a difference with either Methods compared to 20mg PQQ Pre-Workout.
NOTE: Every Time I use PQQ, my Serum Creatinine Levels increase Significantly, between 0.1-0.4 mg/dL on Top of my Baseline Creatinine Levels, which is a lot Higher compared to the increases in Serum Creatinine Levels I get from 5,000mg Creatine HCL per Day. These changes in Creatinine are well Documented in Animal Studies; Creatinine goes up Significantly, while C-Reactive Protein goes down Significantly. After several runs with PQQ Supplementation and improved Workout Capacity, I decided to Discontinue PQQ alltogether as it always increased my Serum Creatinine Levels far Beyond Acceptable Ranges for a 100-115kg Body Builder.
Now Foods Ubiquinol: https://www.iherb.com/pr/Now-Foods-Ubiquinol-100-mg-120-Softgels/57583
California Gold Nutrition PQQ: https://www.iherb.com/pr/California-Gold-Nutrition-PQQ-20-mg-90-Veggie-Softgels/97410
Jarrow Formulas Shilajit Fulvic Acid Complex: https://www.iherb.com/pr/Jarrow-Formulas-Shilajit-Fulvic-Acid-Complex-250-mg-60-Veggie-Caps/42730
Life Extension Super Ubiquinol CoQ10 with PQQ & Shilajit: https://www.iherb.com/pr/Life-Extension-Super-Ubiquinol-CoQ10-with-PQQ-100-mg-30-Softgels/50706
Dose: 1 Capsules of 500mg Boswellia Extract with Breakfast, Lunch and Dinner (3 Capsules per Day, 1,500mg Total) while Cruising, 1 Capsules of 500mg Boswellia Extract with each Meal (4-6 Capsules per Day, 2,000-3,000mg Total) while Blasting
Boswellia Serrata is a Gum Resin Extracted from the Frankinsence Tree. Boswellia Serrata appears to Inhibit a Pro-Inflammatory Enzyme called 5-LipoxyGenase and may possess other Anti-Inflammatory effects by Inhibiting nF-kB Protein Expression. Oral Boswellia Supplementation can Suppress Pain & Immobility associated with Osteo-Arthritis quite Significantly. These Positive Effects take as little as a Week to become Noticeable. Boswellia appears to have promising Anti-Cancer & Tumor benefits, at this point in Time these Studies have only been Performed on Animals & In-Vitro.
By lowering Inflammation in Joints, Tendons & Ligaments, Fluid & Nutrients can readily flow into the Tissue allowing for Increased Recovery and favorable Collagen Synthesis for Strength & Mobility.
A Typical Dose for Body Builders is 3,000mg Boswellia Extract per Day, which can be Split up into 6x 500mg Doses taking with Meals. Most People will Notice Joint Pain Relief & Mobility Improvements within the use of one Bottle of 90 Capsules (13 Days) after which the Dose can be reduced to Maintenance of 3x 500mg per Day with Breakfast, Lunch and Dinner.
Now Foods Boswellia Extract: https://www.iherb.com/pr/Now-Foods-Boswellia-Extract-500-mg-90-Softgels/57586
Curcumin Phytosome (Meriva)
Dose: 1 Capsule of 500mg Curcumin Phytosome with Dinner, perhaps another Capsule of 500mg Curcumin Phytosome with Breakfast & Lunch when Joint-Inflammation is Bothersome or Severe.
Curcumin is a Yellow Pigment primarily found in Turmeric, a Flowering Plant of the Ginger Family. Turmeric is commonly used as Spice in Indian, Thai & Malaysian Curry Dishes. Curcumin is a Polyphenol with Potent Anti-Inflammatory Properties and has the Ability to increase the Amount of Anti-Oxidants that the Body Produces Naturally. Turmeric is Poorly absorbed inside the Intestinal Tract, the Curcumin needs to be Extracted and combined either with Peperine, Lipids (Rhizome Essential Oils) or Soy Lecithin (Meriva). I prefer the Meriva or Rhizome Versions of Curcumin Extract.
Supplementation of Curcumin Extracts reduce Inflammatory Blood Work Markers (C-Reactive Protein & Erythrocyte Sedimentation Rate), contribute to Healthy Serum Lipid & Glucose Levels, improve Insulin Sensitivity, reduce Joint Pain & Joint Inflammation due to Injury or Arthritis, improve Blood Flow & reduce High Blood Pressure.
Similar to Boswellia Extract, Curcumin Extract works by reducing Total Body Inflammation and helps to allow Fluid & Nutrients to flow into the previously Inflamed Tissue. However, Curcumin works more Systemically compared to Boswellia and both Supplement should be used in Combination to improve each other’s Anti-Inflammatory Effects on Joints, Tendons & Ligaments.
In order to Reduce Severe Total Body Inflammation & Elevated C-Reactive Protein Levels, a Daily Dosage of 1,500mg Curcumin Phytosome with Meriva is Required (500mg with Breakfast, Lunch & Dinner). This Dose can be Adjusted depending on the Bio-Availability of the Extract & Supplement Formulation. Once Systemic Inflammation has been reduced, C-Reactive Protein Levels are within the Reference Range (ideally below 1mg/L) and Joint Pain or Discomfort is Acceptable, Curcumin Supplementation can be reduced to 500mg per Day with Dinner.
Jarrow Formulas Curcumin Phytosome (Meriva): https://www.iherb.com/pr/Jarrow-Formulas-Curcumin-Phytosome-with-Meriva-500-mg-120-Veggie-Caps/70839
California Gold Nutrition Curcumin C3 Complex (BioPerine): https://www.iherb.com/pr/California-Gold-Nutrition-Curcumin-C3-Complex-with-BioPerine-500-mg-120-Veggie-Capsules/60047
Astragalus Root Extract
Dose: 4 Capsules of 500mg Astragalus Root Extract with Breakfast & Dinner while Cruising (8 Capsules per Day, 4,000mg Total), 6-8 Capsules of 500mg Astragalus Root Extract with each Breakfast & Dinner while Blasting (12-16 Capsules per Day, 6,000-8,000mg Total), more if Serum Creatinine Levels are elevated.
Astragalus is Herb belonging to the Legume Family Fabaceae & Faboideae. Extracts of Astragalus Root include Diverse Phytochemicals (Saponins & Isoflavone Flavonoids), which have Potent Anti-Oxidant Effects in the Body, as well as Reducing Damage done to the Kidneys and Aiding in Repair of the Glomeruli & Nephrons, restoring Kidney Function Partially or Fully in certain Cases. Most Clinical Studies with Astragalus Root Extract were done on people who suffered Kidney Damage due to Different Diseases, not by the Abuse of PED’s or due to Chronically High Blood Pressure.
The Effects of Astragalus Root Extract on Protecting the Kidneys during Disease States appears to be quite Potent & Reliable, but its Effects on the Kidneys as a Preventative Medicine at Basic Oral Doses below 15g per Day, is not known.
However, Anecdotal Reports on the Kidney Function Restoring Benefits of this Herb have been widely Documented Online by Body Builders & Fitness Enthusiast who used Dosages Ranging from 2-18 Grams per Day, depending on the Severity of the Decline in Kidney Function. The Dose really depends on the decline of Kidney Function, unlike others, with Astragalus Root Extract Supplementation; MORE IS BETTER!
Once Kidney Function has Sufficiently been Restored, the Dose can be reduced to 4,000mg per Day, which is considered to be a Maintenance Dose for Bodybuilders using Moderate amounts of PED’s.
Depending on Serum Creatinine Levels, Astragalus Root Extract Supplementation can range between 2,000mg with Breakfast & Dinner (4,000mg Total), up until 1,500mg with each Meal (9,000mg Total). Personally I use between 4,000-9,000mg Astragalus Root Extract Year Round in order to lower my Serum Creatinine Levels and improve my eGFR Readings on my Blood Work. I increase Astragalus Root Extract Supplementation alongside increases in PED Intake, this keeps my Serum Creatinine around the Top of the Reference Range for my Body Weight & Unnaturally Large Amount of Muscle Mass!
NOTE: Astragalus Root Extract was Popularized by Dante Trudel (DC / DOGGCRAPP Training & Owner of TrueNutrition.com DIY Supplement Website) for Kidney Repair & Health! Since it’s Introduction into the Fitness Industry, Countless Enhanced Body Builders, Powerlifters & Strongmen have added Astragalus Root Extract to their Supplementation Protocol. Many Reported improved Glomerular Filtration Rates (eGFR) and reduce Serum Creatinine Levels withing several Months of using Astragalus.
Now Foods Astragalus Extract: https://www.iherb.com/pr/Now-Foods-Astragalus-Extract-500-mg-90-Veggie-Caps/2487
Dose: 1 Capsule of 500mg Citrus Bergamot with Breakfast & Dinner (2 Capules per Day, 1,000mg Total)
NOTE: Citrus Bergamot & Red Yeast Rice aren’t used in Combination. They are each used in Specific Scenarios, in order to Manage Lipid Levels while using certain PEDs!
Bergamot is a Citrus Fruit that grows Exclusively in the Coastal Region of Southern Italy. Citrus Bergamot Oil is extracted from the Fruit’s Peel and has an Aromatic Scent, thus it’s commonly used as Flavoring in Earl Grey Tea as well as Scent for Perfumes & Aromatherapy.
Citrus Bergamot Extract is derived from the Juice of the Fruit is rich in Bergamot Polyphenols, which have Potent Anti-Oxidant Effects, help to manage Blood Sugar Levels, improve Serum Lipid Levels as well as reduce Fat Deposits inside the Liver (Fatty Liver Disease). Bergamot Polyphenols also Protect the Body against Risk of Cardio-Vascular Disease, Diabetes, Bone Loss / De-Mineralization & Cancer.
Citrus Bergamot Supplementation has been shown to Directly increase Serum HDL Levels, while reducing Total Cholesterol & LDL Levels within or close to the Healthy Reference Range. Enhanced Body Builders or Fitness Enthusiasts might not see Perfect Lipid Levels, especially when Heavy Androgenic Steroids or Potent SARMs are used. Generally Speaking, Citrus Bergamot Supplements are Potent enough to improve HDL:LDL Ratio while Cruising or using mild Anabolics during the Offseason. However, while Blasting on Higher Dosages or Heavy AAS or SARMs, Citrus Bergamot often needs to be replaced with Red Yeast Rice (Natural Statin) in order to keep Total Cholesterol & LDL Levels within Acceptable Parameters!
It’s very difficult to maintain Healthy Levels of HDL while using AAS or SARMs for that matter. However, it is possible to keep HDL above 60mg/dL on a Hormone Replacement Therapy or Cruising Protocol, with Healthy Eating Habits and Fish Oil / Krill Oil Supplementation. Going above 250mg or 1mg / 1lbs Body Weight of Testosterone per Week, or adding other AAS or SARMs, will most certainly lower Serum HDL Levels below 60mg/dL. HDL often falls between 20-40mg/dL depending on which Compounds are being used, even if Serums Estrogen Levels are allowed to reach 100pg/mL or more, which is Gynecomastia Territory. No amount of Health Supplementation will bring your HDL Levels into the Reference Range while Blasting, minimizing the Time you’re using Heavy Androgenic Steroids or Potent SARMs, or High Dosages of PEDs in General will help to keep Lipid Levels close to the Reference Range, for the Majority of the Time you’re using PEDs.
General Recommendations for Lipid Management while using PEDs is 500mg Citrus Bergamot with either Breakfast & Dinner (1,000mg per Day Total). This Dose will suffice to keep Lipid Levels close to the Reference Range, while using “Milder” Compounds like Testosterone, Nandrolone & Boldenone.
Jarrow Formulas Citrus Bergamot: https://www.iherb.com/pr/Jarrow-Formulas-Citrus-Bergamot-500-mg-120-Veggie-Caps/85557
Red Yeast Rice (RYR)
Dose: 1 Capsule of 900mg Red Yeast Rice with Breakfast, perhaps another Capsule of 900mg RYR with Dinner (2 Capsules, 1,800mg Total), when Blasting on Heavy Androgenic Compounds or Potent SARMs.
NOTE: Red Yeast Rice & Citrus Bergamot aren’t used in Combination. They are each used in Specific Scenarios, in order to Manage Lipid Levels while using certain PEDs!
Red Yeast Rice is Fermented Rice that is produced using a Specific Species of Mold. It contains the Compound Monacolin K, which is Chemically Similar to the Active Pharmaceutical Ingredient in Cholesterol-Lowering Prescription Medication; Lovastatin. For this reason most Red Yeast Rice Supplements had to lower their Monacolin K Concentrations to Miniscule Levels, in order not to Compete with the Pharmaceutical Industry.
Red Yeast Rice can be a Cost-Effective Alternative to Pricey Statin Medications when more Potent Cholesterol Management is Required when using Heavy Androgenic Compound while Blasting.
The First 18 Steps in Cholesterol Synthesis Encompass the Mevalonate or HMG-CoA Reductase Pathway. Monacolin K works Preventing the Mevalonate or HMG-CoA Reductase Pathway from occuring, Disabling 19 Additional Steps which come afterwards. These Steps convert Lanosterol into Cholesterol, which can then be converted into Steroid Hormones, Bile Acid & Vitamin D.
By Inhibiting an Essential Step in Cholesterol Synthesis in the Liver as well as other Cholesterol Producing Tissues of the Body, including Adrenal Glands & Reproductive Organs (Testicles or Ovaries), Serum Cholesterol & LDL Levels are reduced in a Dose Dependent Fashion with Red Yeast Rice Supplementation.
NOTE: This is why Red Yeast Rice should NEVER be used while following a Post Cycle Therapy (PCT) as the Testicles & Adrenal Glands require Cholesterol for Healthy Testosterone, DHEA & Pregnenolone Production.
Preliminary Studies indicate that Red Yeast Rice Supplementation might reduce Systemic Inflammation, improve Metabolism and help in the Management of Blood Glucose Levels. How these Benefits compare to Curcumin Phytosome, Boswellia Extract, Fish Oil, Berberine & Apple Cider Vinegar is currently unclear.
General Recommendations for Lipid Management while using PEDs is 900mg Red Yeast Rice with Breakfast, or with Breakfast & Dinner while using Heavy Androgenic Compounds or Potent SARMs. This should prevent Total Cholesterol & LDL Levels from Climbing to Alarmingly High Concentrations, while using Androgenic Compounds like Trenbolone, MENT, Masteron, 17Alpha-Alkylated Oral Steroids or Potent SARMs.
Thorne Research Choleast-900: https://www.iherb.com/pr/Thorne-Research-Choleast-900-120-Capsules/33643
Dose: 1 Capsule of 500mg L-Carnitine-L-Tartrate with each Meal (4-6 Capsules per Day, 2,000-3,000mg Total) during the Offseason, 4 Capsules of 500mg L-Carnitine-L-Tartrate 1 Hour Pre-Workout or Pre-Cardio when Cutting (8 Capsules per Day, 4,000mg Total)
L-Carnitine is a Quaternary Ammonium Compound involved in Metabolism of Short, Medium & Long-Chain Fatty Acids, Creation of Androgen Receptors, Managing Thyroid Levels and Managing ALP, SGPT/ALT, SGOT/AST & Gamma-GT Levels. Cardiac & Skeletal Muscles (the most Metabolically Active Muscle Tissues) contain the Highest Amount of L-Carnitine, where it Accounts for 0.1% of its Dry Mass. Carnitine keeps Liver Markers in the Healthy Range by increased Fatty Acid Metabolism in the Liver, preventing Fatty Liver Disease and protects the Hepatocytes from Destruction while using certain Medication, PED’s or Alcohol. Carnitine also Promotes Cell Membrane Uptake of Gamma-GT, especially when combined with Frequent Coffee Consumption.
When considering L-Carnitine as a Supplement, the L-Tartrate Variation (LCLT) is more Bio-Available for Muscle Tissue compared to Acetyl-L-Carnitine (ALC), which is more Potent in the Brain and has some Nootropic Benefits. LCLT can be taken either in a Single Dose Pre-Workout as Intense Muscular Contractions, increase Carnitine’s absorption into Muscle Tissue, similar to the GLUT4 pathway reducing the Amount of Insulin that is required to absorb Carbohydrates.
ALLMAX Nutrition L-Carnitine-L-Tartrate: https://www.iherb.com/pr/ALLMAX-Nutrition-L-Carnitine-L-Tartrate-Vitamin-B5-1000-mg-120-Vegan-Capsules/67665
Jarrow Formulas L-Carnitine 500: https://www.iherb.com/pr/Jarrow-Formulas-L-Carnitine-500-500-mg-100-Veggie-Caps/136
Dose: 3-5 Capsules of 1,000mg Taurine 1 Hour Pre-Workout (3,000-5,000mg Total)
Probably the most abundant Amino Acid of Cardiac Tissue and is also used in the Central Nervous System. Taurine helps to maintaining proper Hydration and Electrolyte Balance in your Cells, is used to form Bile Salts and regulates the Immune System.
Taurine can help to reduce High Blood Pressure after Ejection from the Heart by Decreasing the Resistance to Blood Flow in your Blood Vessel Walls. Supplementation has been found to reduce Inflammation and Thickening of the Aortic Artery and other Coronary Arteries.
Taurine Supplementation allows Muscles to work Harder and Longer and increases the Muscles’ ability to Contract and Produce Force. It also aids to remove Waste Products that lead to Fatigue and cause Muscle Soreness and protects (Heart) Muscles from Cell Damage from Oxidative Stress! Weightloss has also been linked to Taurine Supplementation, but that’s from the increased Power Output and ability to Exercise Longer.
Taurine plays an Essential Role in Management of Osmotic Pressure between Intra- & Extra-Cellular Fluids. This is most Notable in the Reduction or Complete Mitigation of Lower Back Pumps & Shin Splint, which is a common Side-Effect seen with AAS or SARMs use. Taurine can also reduce Symptoms of Carpal Tunnel, which is common with Growth Hormone or Growth Hormone-Releasing Peptides (GHRPs) use.
A Typical dose is 3,000-5,000mg 1 Hour before Cardio or Training. Most of the Taurine is utilized during Activity and doesn’t increase Taurine content of Tissue, that’s why it needs to be taken before Activity to supply adequate Taurine for increased Power Output of Heart & Skeletal Muscles as well as Healthy CNS Signals to the Heart & Skeletal Muscles!
NOTE: If you’re suffering from Severe Lower Back Pumps, Shin Splints or Carpal Tunnel, a Dose of 1,000-2,000mg Taurine with each Meal is more Beneficial to Mitigate these Side-Effects, compared to a Single Dose of Taurine Pre-Workout. This Dosing Protocol can be Discontinued when Symptoms have subsided!
NOW Foods Taurine Double Strength: https://www.iherb.com/pr/Now-Foods-Taurine-Double-Strength-1-000-mg-250-Veg-Capsules/39933
Mood & Sleep Support
5-Hydroxy-TryptoPhan (5-HTP): Serotonin
Dose: 1 Capsule of 100-200mg 5-HTP with Dinner
5-Hydroxy-TryptoPhan (5-HTP) is a Naturally Occurring Amino Acid & Chemical Pre-Cursor as well as a Metabolic Intermediate in the Bio-Synthesis of the Neuro-Transmitter Serotonin, which plays a Key Role in Mood, Sleep & Appetite.
It is commonly used as a Supplement against Depression as well as replenishing Serotonin Levels after the Recreational use of MDMA, a Party-Drug which Depletes Serotonin Levels Tremendously.
One of the Side Effects of 5-HTP is Drowsiness, which makes it suitable to use before Bed as this Drowsiness helps to make you Fall Asleep Faster. Another commonly Reported Side-Effect is Vivid Dreaming, which is compounded if Melatonin & Growth Hormone are used around the same Time as 5-HTP is used. These Dreams might feel like they Lasted a very Long Time upon Waking, Contributing to Feeling Refreshed & Invigorated upon Waking .
A Typical Dose of 5-HTP is 100-200mg around 1-2 Hours before Bed, as the Drowsiness might take some Time to Manifest. If 5-HTP is taken with Food the Drowsiness is reduced or doesn’t appear to Happen, though the Restful Feeling upon Waking will still be there.
NOTE: 5-HTP Supplementation should’t be combined with MAOI or SSRI Class Anti-Depressants as they Promote Serotonin Re-Uptake in the Brain, which might lead to Serotonin-Syndrome or Toxicity Levels!
California Gold Nutrition 5-HTP: https://www.iherb.com/pr/California-Gold-Nutrition-5-HTP-Mood-Support-Griffonia-Simplicifolia-Extract-from-Switzerland-100-mg-90-Veggie-Capsules/78032
Natrol 5-HTP Time Release Maximum Strength: https://www.iherb.com/pr/Natrol-5-HTP-Time-Release-Maximum-Strength-200-mg-30-Tablets/11872
Dose: 1-2 Tablets of 3mg Melatonin with Dinner (3-6mg Total)
Melatonin is a Hormone that Regulates the Sleep-Wake Cycle. It is Primarily Released by the Pineal Gland. As a Supplement, it is often used as a Short-Term Treatment for Jetlag of Working Night Shift. It helps to simulate Parts of the Circadian Rhythm, even outside of the normal Night Time Sleep Cycles, as Melatonin is involved in Synchronizing the Circadian Rhythm, including Sleep-Wake Timing.
Melatonin seems to most Effective in inducing Sleep Faster and keeping your Asleep until you Transition into Non-REM & REM Sleep Cycles. A typical dose is 3mg Melatonin, 30min before Bed, increasing the Dose to 6mg has not been shown to increase Sleep Onset, Quality or Duration, although many enjoy the Drowsiness that 6mg Melatonin Provides alongside 100-200mg 5-HTP Supplementation.
Now Foods Melatonin: https://www.iherb.com/pr/Now-Foods-Melatonin-3-mg-60-Capsules/14810
Natrol Melatonin: https://www.iherb.com/pr/Natrol-Melatonin-3-mg-240-Tablets/4299
Ashwagandha Root Extract
Dose: 1-2 Tablets of 450mg Ashwagandha Root Extract with Dinner (450-900mg Total)
Cortisol Secretion plays in Important Role in the Circadian Rhythm, where Serum Cortisol is at its lowest around Midnight and slowly starts to Rise approximately 2-3 Hours after Entering Sleep. Cortisol continues to Rise into the early Morning and early Waking Hours, where it reaches its peak in around 9 AM and slowly declines throughout the Day.
In Stressful Situations, Night-Time Serum Cortisol is severely elevated to Levels which are commonly seen around the Time of Waking. Making it difficult to Fall Asleep and enter Non-REM Sleep altogether. This can lead to Sleep Deprivation and reduced Hypothalamus, Pituitary & Adrenal Glands Axis (HPAA) Signaling, further increasing Serum Cortisol Levels, which send a Negative Feedback to the Testicles, lowering Testosterone Production. Although this isn’t really a Problem if you’re Replacing your Natural Testosterone Production, Generously!
In order to control Serum Cortisol Levels and keep them Lowered throughout the Night, as well as upon Waking, you can consider using Ashwagandha Root Extract. Best taken in a Single Dose of 450mg, between 1-2 Hours before going to Sleep. People who have a Stressful Job or are in the later Stages of Contest Prep, can take a Second Dose of 450mg upon Waking. This keeps Cortisol somewhat Suppressed during the Day as well. Not only does Ashwagandha Root Extract help to reduce Cortisol Levels, it’s also known to reduce Anxiety, as well as improving Mood & Energy Levels throughout the Day.
Now Foods Ashwagandha: https://www.iherb.com/pr/Now-Foods-Ashwagandha-450-mg-180-Veg-Capsules/78203
California Gold Nutrition Ashwagandha: https://www.iherb.com/pr/California-Gold-Nutrition-Ashwagandha-450-mg-180-Veggie-Capsules/89863
Dose: 1 Capsule of 176mg before Dinner or Breakfast & Dinner (1-2 Capsules per Day, 352mg Total)
When Oregano Oil is consumed it acts as an Effective Natural ANTI-Viral, Bacterial, Fungal, Microbial & Parasitic Agent, it’s especially helpful against Candida Overgrowth which can cause terrible Digestive Issues. Due to these Properties it can Support the Body’s Immune System to fight against (Stomach) Infections and prevent People from getting Sick from Bacteria, that typically would cause Food Poisoning otherwise, without Oregano Oil Supplementation. Oregano Oil also aids in lowering Cholesterol Levels and Reduce Inflammation in the Body.
In order to improve Digestion and Kill off any Harmful Bacteria in the Gut Micro-Biome, Oregano Oil should first be taken with each Meal. Most Oregano Oil Supplements contain around 100mg Carvacrol per Capsule, which is a Sufficient Dose to take between 4-6 Times per Day before Meals. After 2 Weeks of Continues use, the Gut Micro-Biome has been Positively improved to favor Healthy Bacteria. Oregano Oil Supplementation can then be reduced to a Maintenance Dose of 1 Capsule Oregano Oil containing around 100mg Carvacrol, before Dinner or Breakfast & Dinner.
NOW Foods Oregano Oil: https://www.iherb.com/pr/Now-Foods-Oregano-Oil-90-Softgels/731
Apple Cider Vinegar (ACV)
Dose: 1 Tablet of 750mg Apple Cider Vinegar with Dinner while Cruising, 1 Tablet of 750mg with each Meal while Blasting (4-6 Tablets per Day, 3,000-4,500mg Total)
Apple Cider Vinegar is all the Hype nowadays, because it works, plain and simple. It appears to be Effective at Suppressing the Speed at which Glucose Enters the Blood, which Lowers the Peak of Serum Glucose Levels & Corresponding Insulin Secretion. It is a slowing Effect with regards to Glucose Metabolism, not a reducing Effect. Apple Cider Vinegar Effectively Lowers the Glycemic Index & Glycemic Load of certain Foods, while increasing Micro-Nutrient Uptake from the same Meal!
Unlike Metformin, it doesn’t slow Digestion down, though it does Lower Gastric Emptying, which is the Rate at which Foods Enters the Intestinal Tract. Apple Cider Vinegar allows Food to be in a further State of Digestion once it Enters the Intestinal Tract, allowing for easier Absorption into the Blood Steam. ACV’s main Active Ingredient is Acetic Acid, which also helps to break down Protein & Fats, besides it’s Beneficial Effect on Carbohydrate Absorption & Glucose Metabolism.
Apple Cider Vinegar can be taking in 2 ways:
• 750mg ACV Tablets; 20min before Meals. Make sure you Consume a Decent Amount of Water so the Tablet doesn’t get stuck in your Esophagus. The Tablet might burn a Hole and cause Internal Bleeding if it gets stuck, although it is very very rare for that to happen!
• 25ml Bragg’s ACV with “The Mother”; Diluted in 300ml Water and Consumed 10min before each Meal. Drink this Mixture through a Straw otherwise the Acetic Acid will slowly Dissolve your Teeth’s Enamel Layer when you Drink Diluted ACV Frequently!
Now Foods Apple Cider Vinegar Extra Strength: https://www.iherb.com/pr/Now-Foods-Apple-Cider-Vinegar-Extra-Strength-750-mg-180-Tablets/78990
Natural Factors Apple Cider Vinegar: https://www.iherb.com/pr/Natural-Factors-Apple-Cider-Vinegar-500-mg-180-Capsules/2534